Study of the interactions between pharmaceutical relevant molecules and model membranes : focus on antifungal polyenes and new antimalarial molecules
Identifieur interne : 000162 ( France/Analysis ); précédent : 000161; suivant : 000163Study of the interactions between pharmaceutical relevant molecules and model membranes : focus on antifungal polyenes and new antimalarial molecules
Auteurs : Thierry-Johann Robin [France]Source :
Descripteurs français
English descriptors
- mix :
Abstract
The main purpose of this work is to better understand the mechanisms of interaction between pharmaceutical relevant molecules and model membranes in order to facilitate the synthesis of new molecules, more efficient against their molecular target and less toxic for Humans. In the first part, we studied the interactions occuring between these models and antifungal polyene molecules. It has been reported that these molecules interacted preferentially with sterols. We specifically focused on Nystatin and Amphotericin B, two polyenes with a very similar chemical structure and presently used as a treatment against fungi and molds. Using different kind of model membranes, we showed PhosphatidylEthanolamine could have a very important role in the mechanism of action of these molecules. In the second part of this work, we studied the inhibition of the formation of a cristal called « hemozoïn », which is growing during the life cycle of the parasite responsible of malaria. This cristal is made of hematin, a toxic by-product of the degradation of hemoglobin, the main source of amino-acids for the parasite. Hematin and the inhibition of the growth of this cristal is a ideal molecular target to combat malaria. Chloroquine, mefloquine and new mefloquine-derivatives were studied. The study of the inhibition of the formation of the cristal was done using Langmuir monolayers as a biosensor. We showed that stereochemistry, but also lipophilicity of these compounds, are important parameters for the synthesis of more efficient antimalarial molecules.
Url:
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000221
- to stream Hal, to step Curation: 000221
- to stream Hal, to step Checkpoint: 000111
- to stream Main, to step Merge: 000F89
- to stream Main, to step Curation: 000F88
- to stream Main, to step Exploration: 000F88
- to stream France, to step Extraction: 000162
Links to Exploration step
Hal:tel-01228513Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Study of the interactions between pharmaceutical relevant molecules and model membranes : focus on antifungal polyenes and new antimalarial molecules</title>
<title xml:lang="fr">Etude des interactions molécules d'intérêt pharmacologique/modèles membranaires : cas des polyènes et de nouvelles molécules antipaludiques</title>
<author><name sortKey="Robin, Thierry Johann" sort="Robin, Thierry Johann" uniqKey="Robin T" first="Thierry-Johann" last="Robin">Thierry-Johann Robin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-801" status="VALID"> <orgName>Génie Enzymatique et Cellulaire</orgName>
<orgName type="acronym">GEC</orgName>
<desc> <address> <addrLine>Université de Technologie de Compiègne - Centre de Recherche de Royallieu - rue du Docteur Schweitzer- CS 60319 - 60203 COMPIEGNE Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.utc.fr/umr6022</ref>
</desc>
<listRelation> <relation active="#struct-93027" type="direct"></relation>
<relation active="#struct-300258" type="direct"></relation>
<relation name="UMR6022" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93027" type="direct"><org type="institution" xml:id="struct-93027" status="VALID"> <orgName>Université de Technologie de Compiègne</orgName>
<orgName type="acronym">UTC</orgName>
<desc> <address> <addrLine>Université de Technologie de Compiègne - Centre de Recherche de Royallieu - rue du Docteur Schweitzer- CS 60319 - 60203 COMPIEGNE Cedex </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.utc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300258" type="direct"><org type="institution" xml:id="struct-300258" status="VALID"> <orgName>Université de Picardie Jules Verne</orgName>
<orgName type="acronym">UPJV</orgName>
<desc> <address> <addrLine>Chemin du Thil - 80000 Amiens</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.u-picardie.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6022" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:tel-01228513</idno>
<idno type="halId">tel-01228513</idno>
<idno type="halUri">https://tel.archives-ouvertes.fr/tel-01228513</idno>
<idno type="url">https://tel.archives-ouvertes.fr/tel-01228513</idno>
<date when="2014-12-17">2014-12-17</date>
<idno type="wicri:Area/Hal/Corpus">000221</idno>
<idno type="wicri:Area/Hal/Curation">000221</idno>
<idno type="wicri:Area/Hal/Checkpoint">000111</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000111</idno>
<idno type="wicri:Area/Main/Merge">000F89</idno>
<idno type="wicri:Area/Main/Curation">000F88</idno>
<idno type="wicri:Area/Main/Exploration">000F88</idno>
<idno type="wicri:Area/France/Extraction">000162</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Study of the interactions between pharmaceutical relevant molecules and model membranes : focus on antifungal polyenes and new antimalarial molecules</title>
<title xml:lang="fr">Etude des interactions molécules d'intérêt pharmacologique/modèles membranaires : cas des polyènes et de nouvelles molécules antipaludiques</title>
<author><name sortKey="Robin, Thierry Johann" sort="Robin, Thierry Johann" uniqKey="Robin T" first="Thierry-Johann" last="Robin">Thierry-Johann Robin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-801" status="VALID"> <orgName>Génie Enzymatique et Cellulaire</orgName>
<orgName type="acronym">GEC</orgName>
<desc> <address> <addrLine>Université de Technologie de Compiègne - Centre de Recherche de Royallieu - rue du Docteur Schweitzer- CS 60319 - 60203 COMPIEGNE Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.utc.fr/umr6022</ref>
</desc>
<listRelation> <relation active="#struct-93027" type="direct"></relation>
<relation active="#struct-300258" type="direct"></relation>
<relation name="UMR6022" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93027" type="direct"><org type="institution" xml:id="struct-93027" status="VALID"> <orgName>Université de Technologie de Compiègne</orgName>
<orgName type="acronym">UTC</orgName>
<desc> <address> <addrLine>Université de Technologie de Compiègne - Centre de Recherche de Royallieu - rue du Docteur Schweitzer- CS 60319 - 60203 COMPIEGNE Cedex </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.utc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300258" type="direct"><org type="institution" xml:id="struct-300258" status="VALID"> <orgName>Université de Picardie Jules Verne</orgName>
<orgName type="acronym">UPJV</orgName>
<desc> <address> <addrLine>Chemin du Thil - 80000 Amiens</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.u-picardie.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6022" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antifungal polyene molecules</term>
<term>Antimalarial molecules</term>
<term>Biosensors</term>
<term>Langmuir monolayers</term>
<term>Model membranes</term>
</keywords>
<keywords scheme="mix" xml:lang="fr"><term>Hématine</term>
<term>Hémozoïne</term>
<term>Modèles membranaires</term>
<term>Nystatine</term>
<term>PhosohatidylEthanolamine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>The main purpose of this work is to better understand the mechanisms of interaction between pharmaceutical relevant molecules and model membranes in order to facilitate the synthesis of new molecules, more efficient against their molecular target and less toxic for Humans. In the first part, we studied the interactions occuring between these models and antifungal polyene molecules. It has been reported that these molecules interacted preferentially with sterols. We specifically focused on Nystatin and Amphotericin B, two polyenes with a very similar chemical structure and presently used as a treatment against fungi and molds. Using different kind of model membranes, we showed PhosphatidylEthanolamine could have a very important role in the mechanism of action of these molecules. In the second part of this work, we studied the inhibition of the formation of a cristal called « hemozoïn », which is growing during the life cycle of the parasite responsible of malaria. This cristal is made of hematin, a toxic by-product of the degradation of hemoglobin, the main source of amino-acids for the parasite. Hematin and the inhibition of the growth of this cristal is a ideal molecular target to combat malaria. Chloroquine, mefloquine and new mefloquine-derivatives were studied. The study of the inhibition of the formation of the cristal was done using Langmuir monolayers as a biosensor. We showed that stereochemistry, but also lipophilicity of these compounds, are important parameters for the synthesis of more efficient antimalarial molecules.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Robin, Thierry Johann" sort="Robin, Thierry Johann" uniqKey="Robin T" first="Thierry-Johann" last="Robin">Thierry-Johann Robin</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000162 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000162 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= France |étape= Analysis |type= RBID |clé= Hal:tel-01228513 |texte= Study of the interactions between pharmaceutical relevant molecules and model membranes : focus on antifungal polyenes and new antimalarial molecules }}
This area was generated with Dilib version V0.6.33. |